The comorbidity of chronic pain and opioid addiction is a serious problem that has been growing with the practice of prescribing opioids for chronic pain. Neuroimaging research has shown that chronic pain and opioid dependence both affect brain structure and function, but this is the first study to evaluate the neurophysiological alterations in patients with comorbid chronic pain and addiction. Eighteen participants with chronic low back pain and opioid addiction were compared with eighteen age- and sex-matched healthy individuals in a (...) pain-induction fMRI task. Unified structural equation modeling (SEM) with Lagrange multiplier (LM) testing yielded a network model of pain processing for patient and control groups based on 19 a priori defined regions. Tests of differences between groups on specific regression parameters were determined on a path-by-path basis using z-tests corrected for the number of comparisons. Patients with the chronic pain and addiction comorbidity had increased connection strengths; many of these connections were interhemispheric and spanned regions involved in sensory, affective, and cognitive processes. The affected regions included those that are commonly altered in chronic pain or addiction alone, indicating that this comorbidity manifests with neurological symptoms of both disorders. Understanding the neural mechanisms involved in the comorbidity is crucial to finding a comprehensive treatment, rather than treating the symptoms individually. (shrink)

This book explores the universe and its subsystems from the three lenses of evolutionary (diversifying), developmental (converging), and complex (adaptive) processes at all scales. It draws from prolific experts within the academic disciplines of complexity science, physical science, information and computer science, theoretical and evo-devo biology, cosmology, astrobiology, evolutionary theory, developmental theory, and philosophy. The chapters come from a Satellite Meeting, "Evolution, Development and Complexity" (EDC) hosted at the Conference on Complex Systems, in Cancun, 2017. The contributions will be peer-reviewed (...) and contributors from outside the conference will be invited to submit chapters to ensure full coverage of the topics. This book explores many issues within the field of EDC such as the interaction of evolutionary stochasticity and developmental determinism in biological systems and what they might teach us about these twin processes in other complex systems. This text will appeal to students and researchers within the complex systems and EDC fields.. (shrink)

This study examines the outcomes of a four-year faculty learning community (FLC) that aimed to transform departmental ethics curriculum by supporting Earth Sciences faculty members as they ethically inquired into their teaching of ethics and refined existing courses in alignment with an Integrated Community-Engaged Learning and Ethical Reflection (ICELER) framework. We present ethnographic case studies that unpack processes through which three faculty members transformed undergraduate courses. We assembled case studies by triangulating interview data, course artifacts, and faculty reflections. We examine (...) how faculty (1) built awareness around teaching ethics, (2) took responsibility for and made judgments about teaching ethics, (3) experimented by designing and implementing ICELER-inspired courses, and (4) interrogated the outcomes of their ethics teaching, utilizing findings to enhance awareness and revise courses. The paper closes by introducing a model detailing how instructors inquire into ethics teaching and how model components might inspire future educational practice and research. (shrink)

Introduction: Schools have become a primary setting for providing mental health care to youths in the U.S. School-based interventions have proliferated, but their effects on mental health and academic outcomes remain understudied. In this study we will implement and evaluate the effects of a flexible multidiagnostic treatment called Modular Approach to Therapy for Children with Anxiety, Depression, Trauma, or Conduct Problems on students' mental health and academic outcomes.Methods and Analysis: This is an assessor-blind randomized controlled effectiveness trial conducted across five (...) school districts. School clinicians are randomized to either MATCH or usual care treatment conditions. The target sample includes 168 youths referred for mental health services and presenting with elevated symptoms of anxiety, depression, trauma, and/or conduct problems. Clinicians randomly assigned to MATCH or UC treat the youths who are assigned to them through normal school referral procedures. The project will evaluate the effectiveness of MATCH compared to UC on youths' mental health and school related outcomes and assess whether changes in school outcomes are mediated by changes in youth mental health.Ethics and Dissemination: This study was approved by the Harvard University Institutional Review Board. We plan to publish the findings in peer-reviewed journals and present them at academic conferences.Clinical Trial Registration:ClinicalTrials.gov ID: NCT02877875. Registered on August 24, 2016. (shrink)

We discuss some research that has examined approach motivational urges and how this research clarifies the definition of approach motivation. Our research and that of others have raised doubts about the commonly accepted definition of approach motivation, which views it as a positive affective state triggered by positive stimuli. We review evidence that suggests: (a) that approach motivation is occasionally evoked by negative stimuli; (b) that approach motivation may be experienced as a negative state; and (c) that stimuli are unnecessary (...) to evoke approach motivation. (shrink)

There are thirteen essays in this collection. Sophisticated disquisitions on rather disparate topics, they contain a number of statements which are obscure to me and, I wager, to many readers, including metaphysicians. There is space here to note only a few of the several recurrent themes in Miller’s essays. First and foremost is the notion of the primacy of action. The affirmation of values, he says, is not a "matter of logic but of action," and "values become real only in (...) the deed"—values being prior to mere facts. Miller’s action-philosophy entails an exaltation of will over intellect. For instance, he says that "the pursuit of truth is itself a gesture of will." Another recurrent theme is the human inescapability of history—of time, process, transitoriness, corruptibility. What Miller calls "ahistorical sublimity" is purchased at too high a price-the price of a "radical impersonality" with an "apparent irrelevance to action and values." Miller’s view of freedom can be called intellectualist: "It is," he says, "in the ‘revision’ of truth that freedom is found." He refers not to "static" truth in the impersonal mode of physics but to dynamic truth in the mode of personal creativity. For "creative adventure," by action and experiment, he holds, is the mark of freedom. The entire "midworld" of artifacts, including arts, sciences, and languages, is the province of "responsible freedom." This whole area should be marked by "skepticism" as well as freedom, because skepticism is man’s best weapon against "absolutist pretensions," Miller persuasively argues. Furthermore, he stresses the point that there is no fact within our ken which is not linguistically expressible, so that "responsible humanism" is inconceivable without responsible use of language. The desideratum, as Miller says, is "controlled receptivity" regarding the employment of all linguistic signs and instruments. For "nature," the common object of all our knowledge, embraces not only facts but artifacts as well, including languages. He says that only "purposeful artifacts"-especially languages—put us in touch with actuality and history. History alone, he argues, leads into philosophy. "Ahistoric ideals," present everywhere in classical thought, stand in the way of this wedding of history and philosophy. A happy wedding for, according to Miller, there is no human knowledge that is not historical; everything human is dated. Miller is an action-philosopher because he is a history-philosopher. He contends that there is no freedom for us outside of history. He hails skepticism regarding "ahistoric ideals" as a kind of "negative absolutism." And he says that such skepticism is an "experience, not a theory," and that it makes "metaphysics of the transcendent" possible. He does not explain what that metaphysics is. Apparently, his "skepticism" is the awareness of the limited character of all philosophies. If so, it is, for Miller, our chief safeguard against the use of bloated language in the service of the ahistoric ideal.—J.F.A. (shrink)

Originally published in 1954, on behalf of the National Institute of Economic and Social Research, this book presents a general review of British economic statistics in relation to the uses made of them for policy purposes. The text begins with an examination, in general terms, of the ways in which statistics can help in guiding or assessing policy, covering housing, coal, the development areas, agricultural price-fixing, the balance of external payments and the balance of the economy. The problems of (...) statistical application are then separately discussed under the headings of quality, presentation and availability, and organization. A full bibliography and reference table of principal British economic statistics are also included. This book will be of value to anyone with an interest in British economic history and statistics. (shrink)

Abstract:Antarctica has long been associated with the sublime and it has also been imagined as the site of catastrophe—of both the deaths of early explorers and as a current indicator of global warming. This essay examines how trauma is a structural element of the sublime in accounts and images of Antarctica. It focuses on the literary and artistic works of two periods when representation of the experience of the continent has been articulated with discourses of trauma: the ‘Heroic Age’ of (...) Antarctic exploration and from the 1990s to the present day. In this latter period writers, photographers and artists have returned to the matrix of the traumatic sublime that the work of explorers such as R. F. Scott, Apsley Cherry-Garrard, and Herbert Ponting created to explore the relationship between humans and the non-human environment and of Antarctica to modernity. (shrink)

Is helping those whose subsistence needs are not meet a matter of charity or an obligation? What role should ordinary citizens of developed nations play? In a globalized world, the causes, connections, and responsibilities become complicated. Agriculture subsidies that keep food prices low for many in relatively rich countries may, for example, negatively impact poor farmers in developing countries. Students in Ethics/Philosophy 352 report on their project examining whether, and to what extent, a true obligation to aid exists.